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Role of the pontine respiratory group in the suppression of cough by codeine in cats.
- Source :
-
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2024 Dec; Vol. 330, pp. 104326. Date of Electronic Publication: 2024 Aug 28. - Publication Year :
- 2024
-
Abstract
- Codeine was microinjected into the area of the Kölliker-Fuse nucleus and the adjacent lateral parabrachial nucleus, within the pontine respiratory group in 8 anesthetized cats. Electromyograms (EMGs) of the diaphragm (DIA) and abdominal muscles (ABD), esophageal pressures (EP), and blood pressure were recorded and analyzed during mechanically induced tracheobronchial cough. Unilateral microinjections of 3.3 mM codeine (3 injections, each 37 ± 1.2 nl) had no significant effect on the cough number. However, the amplitudes of the cough ABD EMG, expiratory EP and, to a lesser extent, DIA EMG were significantly reduced. There were no significant changes in the temporal parameters of the cough. Control microinjections of artificial cerebrospinal fluid in 6 cats did not show a significant effect on cough data compared to those after codeine microinjections. Codeine-sensitive neurons in the rostral dorsolateral pons contribute to controlling cough motor output, likely through the central pattern generator of cough.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cats
Microinjections
Male
Pons drug effects
Antitussive Agents pharmacology
Antitussive Agents administration & dosage
Female
Blood Pressure drug effects
Blood Pressure physiology
Kolliker-Fuse Nucleus drug effects
Kolliker-Fuse Nucleus physiology
Diaphragm drug effects
Diaphragm physiopathology
Parabrachial Nucleus drug effects
Parabrachial Nucleus physiology
Abdominal Muscles drug effects
Cough drug therapy
Cough physiopathology
Codeine pharmacology
Codeine administration & dosage
Electromyography
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1519
- Volume :
- 330
- Database :
- MEDLINE
- Journal :
- Respiratory physiology & neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 39209015
- Full Text :
- https://doi.org/10.1016/j.resp.2024.104326