Impact of HLA allele-KIR partners on sexually transmitted HIV-1 infection.

Authors :: Serrano-Rísquez C
Omar M
Rallón N
Benito JM
Gómez-Vidal A
Márquez FJ
Alján M
Rivero-Juárez A
Pérez-Valero I
Rivero A
Sinangil F
Saulle I
Biasin M
Clerici M
Forthal D
Saéz ME
Caruz A
Source :: The Journal of infectious diseases [J Infect Dis] 2024 Aug 29. Date of Electronic Publication: 2024 Aug 29.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: HLA-I/KIR genotypes influence HIV-1 disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral vs. sexual-may influence this association. We conducted a GWAS in a population of people living with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)