Back to Search
Start Over
IFITM10 Enhance Tumor Angiogenesis and Promotes Cancer Progression through STAT3 Activation.
- Source :
-
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Aug 16; Vol. 29 (8), pp. 283. - Publication Year :
- 2024
-
Abstract
- Background: Humankind have been struggling with colorectal cancer (CRC) for long period with its rapid progression and invasive metastasis. By hyperactivating IL-6/STAT3 signaling, CRC facilitates the capacity of angiogenesis to plunder massive nutrients and develops gradually under harsh condition.<br />Methods: The Cancer Genome Atlas database was analyzed for acquiring interferon-γ inducible protein 10 ( IFITM10 ) expression levels and their correlation with clinical outcomes. The cell angiogenic ability were assessed by Cell Counting Kit-8 (CCK-8) and tube formation assay. Immunofluorescence, Western blot, and enzyme-linked immunosorbent assay (ELISA) assay were using to assess potential mechanism.<br />Results: In our study, we find that IFITM10 is upregulated in CRC and is positively related with tumor angiogenesis. We also find that IFITM inhibition decreased STAT3 phosphorylation level and IFITM10-mediated angiogenesis depends on STAT3 activation. Furthermore, our data suggests that IFITM10 may be a key prognostic biomarker in colorectal cancer.<br />Conclusion: Together, our study suggests that IFITM10 enhance angiogenesis through STAT3 activation during CRC progression, which highlighting its potency as a therapeutic target for colorectal cancer.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2024 The Author(s). Published by IMR Press.)
- Subjects :
- Humans
Cell Line, Tumor
Signal Transduction
Gene Expression Regulation, Neoplastic
Human Umbilical Vein Endothelial Cells metabolism
Phosphorylation
Prognosis
Biomarkers, Tumor metabolism
Biomarkers, Tumor genetics
Angiogenesis
Antigens, Differentiation
STAT3 Transcription Factor metabolism
Neovascularization, Pathologic metabolism
Neovascularization, Pathologic genetics
Disease Progression
Colorectal Neoplasms pathology
Colorectal Neoplasms metabolism
Colorectal Neoplasms genetics
Colorectal Neoplasms blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 2768-6698
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Landmark edition)
- Publication Type :
- Academic Journal
- Accession number :
- 39206889
- Full Text :
- https://doi.org/10.31083/j.fbl2908283