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Sex- and Age-Specific Differences in Mice Fed a Ketogenic Diet.
- Source :
-
Nutrients [Nutrients] 2024 Aug 16; Vol. 16 (16). Date of Electronic Publication: 2024 Aug 16. - Publication Year :
- 2024
-
Abstract
- The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that results in the elevation of serum ketone bodies, known as ketosis. This metabolic consequence has been suggested as a method for treating neurological conditions, improving exercise performance, and facilitating weight loss for overweight individuals. However, since most research primarily uses male populations, little is known about the potential sex differences during the consumption of the KD. In addition, the effects of the KD on aging are relatively unexplored. Therefore, the purpose of this study was to explore sex- and age-specific differences in mice fed the KD. Male and female C57BL/6N mice at either 12 wks or 24 wks of age were randomly assigned to a KD (90% fat, 1% carbohydrate) or chow (13% fat, 60% carbohydrate) group for 6 wks. KD induced weight gain, increased adiposity, induced hyperlipidemia, caused lipid accumulation in the heart and liver, and led to glycogen depletion in the heart, liver, and muscle with varying degrees of changes depending on age and sex. While younger and older male mice on the KD were prone to glucose intolerance, the KD acutely improved rotarod performance in younger females. Overall, this study highlights potential sex and aging differences in the adaptation to the KD.
- Subjects :
- Animals
Male
Female
Sex Factors
Mice
Age Factors
Adiposity
Aging physiology
Glycogen metabolism
Weight Gain
Hyperlipidemias diet therapy
Hyperlipidemias etiology
Lipid Metabolism
Glucose Intolerance
Sex Characteristics
Muscle, Skeletal metabolism
Myocardium metabolism
Diet, Ketogenic
Mice, Inbred C57BL
Liver metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 16
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 39203867
- Full Text :
- https://doi.org/10.3390/nu16162731