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Relationship between Markers of Gut Barrier Function and Erythrocyte Membrane PUFAs in Diarrhea-Predominant IBS Patients Undergoing a Low-FODMAP Diet.
- Source :
-
Nutrients [Nutrients] 2024 Aug 14; Vol. 16 (16). Date of Electronic Publication: 2024 Aug 14. - Publication Year :
- 2024
-
Abstract
- Many patients with irritable bowel syndrome (IBS) have a compromised intestinal barrier associated with low-grade inflammation. Polyunsaturated fatty acids (PUFAs) are potential mediators of inflammation: omega-6 PUFAs are pro-inflammatory, while omega-3 PUFAs are antioxidant and anti-inflammatory. Zonulin is a potential biomarker for small intestinal permeability (s-IP). This study investigated the relationship between PUFAs and gastrointestinal (GI) barrier integrity in IBS patients with predominant diarrhea (IBS-D). We evaluated GI barrier function indicators in the urine and bloodstream and erythrocyte membrane PUFA composition in 38 IBS-D patients (5 men, 33 women, 44.11 ± 1.64 years), categorized at baseline by fecal zonulin levels into high (≥107 ng/mL, H-FZ) and normal (<107 ng/mL N-FZ) groups. Evaluations were conducted prior to and following a 12-week diet low in FODMAPs (LFD). At baseline, H-FZ patients had s-IP significantly higher than the reference value, lower n -3 PUFAs levels, and higher n -6/ n -3 PUFAs and arachidonic acid (AA) to eicosapentaenoic acid (EPA) ratios than N-FZ. After LFD, H-FZ patients showed significant increases in n -3 PUFAs levels; decreases in n -6 PUFAs, n -6/ n -3 PUFAs and AA/EPA ratios; and improved s-IP. The n -6/ n -3 PUFAs ratio positively correlated with fecal zonulin levels in all subjects. These findings highlight the relationship between PUFAs and the intestinal barrier, suggesting their role in IBS-D pathophysiology and confirming the positive effects of LFD in managing IBS-D.
- Subjects :
- Humans
Female
Male
Adult
Middle Aged
Permeability
Feces chemistry
Fatty Acids, Omega-3 analysis
Fatty Acids, Unsaturated analysis
Protein Precursors metabolism
Intestinal Mucosa metabolism
Cholera Toxin
FODMAP Diet
Irritable Bowel Syndrome diet therapy
Diarrhea etiology
Haptoglobins metabolism
Biomarkers urine
Erythrocyte Membrane metabolism
Erythrocyte Membrane chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 16
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 39203842
- Full Text :
- https://doi.org/10.3390/nu16162706