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Impact of Peripheral Angioplasty on Wound Oxygenation and Healing in Patients with Chronic Limb-Threatening Ischemia Measured by Near-Infrared Spectroscopy.
- Source :
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Biomedicines [Biomedicines] 2024 Aug 08; Vol. 12 (8). Date of Electronic Publication: 2024 Aug 08. - Publication Year :
- 2024
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Abstract
- Managing chronic limb-threatening ischemia (CLTI) is challenging due to difficulties in assessing tissue oxygen saturation in ulcers. Near-infrared spectroscopy (NIRS) is a non-invasive method for measuring tissue oxygen saturation (StO <subscript>2</subscript> ). This study evaluated the effects of endovascular treatment (EVT) on StO <subscript>2</subscript> and wound healing in CLTI patients, comparing NIRS to standard ankle-brachial index (ABI) measurements. Using the Duesseldorf PTA Registry, 43 CLTI patients were analyzed: 27 underwent EVT, and 16 received conservative treatment. ABI assessed macrocirculation, while NIRS measured wound, wound area, and mean foot StO <subscript>2</subscript> at baseline, post-EVT, and four-month follow-up. Wound severity was classified by wound area and wound, ischemia, and foot infection (WIfI) score. Wound StO <subscript>2</subscript> increased significantly (median (interquartile range (IQR)), 38 (49.3) to 60 (34.5)%, p = 0.004), as did wound area StO <subscript>2</subscript> (median (IQR), 70.9 (21.6) to 72.8 (18.3)%, p < 0.001), with no significant changes in the control group by four-month follow-up. Wound area decreased significantly after EVT (mean ± SD, 343.1 ± 267.8 to 178.1 ± 268.5 mm <superscript>2</superscript> , p = 0.01) but not in the control group. Changes in wound StO <subscript>2</subscript> , wound area StO <subscript>2</subscript> , and WIfI score correlated with wound area reduction, unlike ABI. This small exploratory study shows that NIRS-measured StO <subscript>2</subscript> improvements after EVT correlate with reduced wound area and WIfI scores, highlighting NIRS as a potential enhancement for CLTI wound management in addition to ABI.
Details
- Language :
- English
- ISSN :
- 2227-9059
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biomedicines
- Publication Type :
- Academic Journal
- Accession number :
- 39200269
- Full Text :
- https://doi.org/10.3390/biomedicines12081805