Back to Search
Start Over
The Influence of β-Carotene and Its Liposomal Form on the Expression of EMT Markers and Androgen-Dependent Pathways in Different Prostate Cell Lines.
- Source :
-
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Jul 25; Vol. 13 (8). Date of Electronic Publication: 2024 Jul 25. - Publication Year :
- 2024
-
Abstract
- Prostate cancer (PCa) is the most common malignancy in men. Although the prognosis in the early stages is good, the treatment of advanced PCa remains a formidable challenge. Even after an initial response to hormone therapy or chemotherapy, recurrences are frequent and resistance to any systemic treatment is common. β-Carotene (BC), a plant-derived tetraterpene, is known for its antioxidant capacity and can modulate multiple cellular signaling pathways, potentially affecting androgen synthesis. We investigated the influence of BC (dissolved in EtOH/THF with a cell culture medium or encapsulated in liposomes (LP-BCs)) on the viability, migration potential, and connective tissue cleavage capabilities of several PCa cell lines (Du145, LNCaP, PC-3, and 22Rv1) and a healthy prostate model (RWPE cells). BC significantly reduced the proliferative capacity of all investigated cell lines at various concentrations (1.5-30 µM) and decreased cell migration. However, it significantly increased the expression of epidermal-mesenchymal transition (EMT) master proteins in all cancer cell lines and RWPE ( p < 0.05) These effects were not observed with LP-BCs. This study suggests that LP-BCs, with their higher antiproliferative capabilities and pronounced inhibition of the EMT, may be a more effective form of possible PCa prevention or treatment than the free form. LPs may also modulate lipid metabolism in PCa cells.
Details
- Language :
- English
- ISSN :
- 2076-3921
- Volume :
- 13
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antioxidants (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 39199148
- Full Text :
- https://doi.org/10.3390/antiox13080902