Back to Search
Start Over
Differences in Efficacy between Antibacterial Lock Therapy and the Standard of Care for CVC-Related Infections: A Systematic Review and Meta-Analysis.
- Source :
-
Clinics and practice [Clin Pract] 2024 Aug 09; Vol. 14 (4), pp. 1538-1549. Date of Electronic Publication: 2024 Aug 09. - Publication Year :
- 2024
-
Abstract
- Background : Central Venous Catheter (CVC)-related infections cannot always be solved by replacement, due to some vascular anomalies or an emergency status. This comprehensive, evidence-based review aimed to define the efficacy of antibacterial lock therapy (ALT) compared to the standard of care (SoC) in CVC-related infections. Methods : We performed a systematic search in PubMed, Embase, and Google Scholar, looking for randomized controlled trials (RCTs) and cohort or case-control observational studies. The eligible studies considered the subjects with a diagnosis of CVC-related infections treated with antibacterial lock therapy (ALT) compared to the standard of care (SoC). Results: Among 609 records at the end of the selection process, five articles, referring to observational studies, were included in this systematic review. In pooled analyses, including a total of 276 individuals, microbiological healing (OR 3.78; 95% CI; 2.03-7.03) showed significant differences between ALT and the SoC, with a follow-up varying from 2 weeks to 3 months. Conclusions: Our results suggested that ALT could improve the preservation of CVCs and could be considered when their replacement is not possible as a result of vascular problems. However, only observational studies were included and RCTs are needed to confirm these findings and to increase the level of evidence.
Details
- Language :
- English
- ISSN :
- 2039-7275
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinics and practice
- Publication Type :
- Academic Journal
- Accession number :
- 39194928
- Full Text :
- https://doi.org/10.3390/clinpract14040124