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Weak mutagenicity to Salmonella of the formaldehyde-releasing anti-tumour agent hexamethylmelamine.
- Source :
-
Mutation research [Mutat Res] 1985 Mar; Vol. 142 (3), pp. 121-5. - Publication Year :
- 1985
-
Abstract
- Hexamethylmelamine (HEMLA) is a metabolism-dependent formaldehyde-releasing agent related in structure to hexamethylphosphoramide (HMPA). Both compounds are known to be mutagenic to Drosophila. HMPA, in common with the other formaldehyde-releasing agents studied, is non-mutagenic to Salmonella. The present paper describes the mutagenicity of HEMLA to strain TA100 of Salmonella typhimurium. Activity is dependent upon both the use of a pre-incubation assay protocol and on high concentrations of Aroclor-induced rat liver in the S9 mix. HMPA was inactive under similar conditions of test.
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 142
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 3919288
- Full Text :
- https://doi.org/10.1016/0165-7992(85)90051-x