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Weak mutagenicity to Salmonella of the formaldehyde-releasing anti-tumour agent hexamethylmelamine.

Authors :
Ashby J
Callander RD
Rose FL
Source :
Mutation research [Mutat Res] 1985 Mar; Vol. 142 (3), pp. 121-5.
Publication Year :
1985

Abstract

Hexamethylmelamine (HEMLA) is a metabolism-dependent formaldehyde-releasing agent related in structure to hexamethylphosphoramide (HMPA). Both compounds are known to be mutagenic to Drosophila. HMPA, in common with the other formaldehyde-releasing agents studied, is non-mutagenic to Salmonella. The present paper describes the mutagenicity of HEMLA to strain TA100 of Salmonella typhimurium. Activity is dependent upon both the use of a pre-incubation assay protocol and on high concentrations of Aroclor-induced rat liver in the S9 mix. HMPA was inactive under similar conditions of test.

Details

Language :
English
ISSN :
0027-5107
Volume :
142
Issue :
3
Database :
MEDLINE
Journal :
Mutation research
Publication Type :
Academic Journal
Accession number :
3919288
Full Text :
https://doi.org/10.1016/0165-7992(85)90051-x