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Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages.
- Source :
-
Clinical and translational medicine [Clin Transl Med] 2024 Sep; Vol. 14 (9), pp. e70014. - Publication Year :
- 2024
-
Abstract
- A recent study outlines the phenotypes of brain border region macrophages in developing, normal and glioblastoma-affected brains. For the first time, the authors show in-vivo turnover of human brain border macrophages. The findings have implications for the understanding of brain border immunity and potential macrophage targeting therapies. KEYPOINTS: Human border region macrophages are distinct from microglia. These distinct phenotypes are established early during embryonal development - Brain border macrophages are partially replaced by bone marrow-derived myeloid cells. The transcriptional phenotypes of glioblastoma-associated macrophage are determined by the anatomical region.<br /> (© 2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.)
- Subjects :
- Humans
Brain immunology
Macrophages immunology
Macrophages metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2001-1326
- Volume :
- 14
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical and translational medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39192506
- Full Text :
- https://doi.org/10.1002/ctm2.70014