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[Effect of Collagen Peptides on Function of Mouse T Lymphocytes under Simulated Microgravity].
- Source :
-
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2024 Aug; Vol. 32 (4), pp. 1258-1263. - Publication Year :
- 2024
-
Abstract
- Objective: To understand the effect of collagen peptides on the function of mouse lymphocytes under simulated microgravity.<br />Methods: The splenocytes of mice were isolated, and the rotary cell culture system was used to simulate the microgravity. The T lymphocytes were stimulated with mitotic agents, concanavalin A (ConA), and the cells were treated with different concentrations of collagen peptides. The proliferation of lymphocytes and the levels of cytokines in the supernatant were detected.<br />Results: Simulated microgravity could inhibit the proliferation of spleen T lymphocytes and decrease the level of cytokines in the supernatant. Collagen peptides could promote the lymphocyte proliferation and cytokine production in cells cultured under simulated microgravity.<br />Conclusion: Collagen peptides may attenuate the inhibitory effect of simulated microgravity on T lymphocytes by regulating the cell proliferation and the secretion of cytokines.
Details
- Language :
- Chinese
- ISSN :
- 1009-2137
- Volume :
- 32
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo shi yan xue ye xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 39192428
- Full Text :
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.04.043