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Safety of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease.
- Source :
-
Expert opinion on drug metabolism & toxicology [Expert Opin Drug Metab Toxicol] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Introduction: Proton pump inhibitors (PPIs) are the first-line treatment for gastroesophageal reflux disease (GERD). However, due to their intrinsic limitations, there are still unmet clinical needs that have fostered the development of potassium-competitive acid blockers (p-CABs). Currently, four different drugs (vonoprazan, tegoprazan, fexuprazan, keverprazan) are marketed in some Asian countries, whereas only vonoprazan and tegoprazan are available in Western countries (U.S.A. and Brazil or Mexico, respectively).<br />Areas Covered: This review summarizes the current knowledge on p-CABs acute and long-term safety in GERD treatment compared to that of PPIs. Full-text articles and abstracts were searched in PubMed.<br />Expert Opinion: p-CABs proved to address some of the unmet clinical needs in GERD, with a favorable risk-benefit ratio compared to conventional PPIs. Preclinical and clinical findings have highlighted p-CAB safety to be superimposable, to that of PPIs, in short-term treatments, although further studies are warranted to monitor their effects in long-term therapy. From an epidemiological point of view, the paucity of rigorous data for many variables (e.g. age, ethnicity, drug interactions, comorbidities, genetic polymorphisms, interindividual susceptibility, microbial dysbiosis) deserves a worldwide framework of continuous pre/post-marketing pharmacovigilance programs to reduce potential confounding factors and accurately link acute and chronic p-CAB therapy to adverse outcomes.
Details
- Language :
- English
- ISSN :
- 1744-7607
- Database :
- MEDLINE
- Journal :
- Expert opinion on drug metabolism & toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 39189409
- Full Text :
- https://doi.org/10.1080/17425255.2024.2397433