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Neuritin accelerates Schwann cell dedifferentiation via PI3K/Akt/mTOR signalling pathway during Wallerian degeneration.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Aug; Vol. 28 (16), pp. e70012. - Publication Year :
- 2024
-
Abstract
- Neuritin, also known as candidate plasticity gene 15 (CPG15), was first identified as one of the activity-dependent gene products in the brain. Previous studies have been reported that Neuritin induces neuritogenesis, neurite arborization, neurite outgrowth and synapse formation, which are involved in the development and functions of the central nervous system. However, the role of Neuritin in peripheral nerve injury is still unknown. Given the importance and necessity of Schwann cell dedifferentiation response to peripheral nerve injury, we aim to investigate the molecular mechanism of Neuritin steering Schwann cell dedifferentiation during Wallerian degeneration (WD) in injured peripheral nerve. Herein, using the explants of sciatic nerve, an ex vivo model of nerve degeneration, we provided evidences indicating that Neuritin vividly accelerates Schwann cell dedifferentiation. Moreover, we found that Neuritin promotes Schwann cell demyelination as well as axonal degeneration, phagocytosis, secretion capacity. In summary, we first described Neuritin acts as a positive regulator for Schwann cell dedifferentiation and WD after peripheral nerve injury.<br /> (© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
- Subjects :
- Animals
GPI-Linked Proteins metabolism
GPI-Linked Proteins genetics
Rats
Peripheral Nerve Injuries metabolism
Peripheral Nerve Injuries pathology
Rats, Sprague-Dawley
Axons metabolism
Axons pathology
Male
Phagocytosis
Mice
Schwann Cells metabolism
Schwann Cells pathology
Wallerian Degeneration metabolism
Wallerian Degeneration pathology
Cell Dedifferentiation
TOR Serine-Threonine Kinases metabolism
Signal Transduction
Proto-Oncogene Proteins c-akt metabolism
Phosphatidylinositol 3-Kinases metabolism
Neuropeptides metabolism
Neuropeptides genetics
Sciatic Nerve injuries
Sciatic Nerve metabolism
Sciatic Nerve pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 28
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39187917
- Full Text :
- https://doi.org/10.1111/jcmm.70012