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Pre- and postoperative OCT features and surgical outcomes of advanced retinitis pigmentosa with macular hole: case series and literature review.

Authors :
Song Y
Zhang Y
Si Y
Wu S
Xiu M
Zhu J
Cui Y
Source :
BMC ophthalmology [BMC Ophthalmol] 2024 Aug 26; Vol. 24 (1), pp. 370. Date of Electronic Publication: 2024 Aug 26.
Publication Year :
2024

Abstract

Background: Macular hole (MH) is a rare complication of retinitis pigmentosa (RP) and has an adverse impact on residual visual function. At present, the underlying mechanisms are not fully understood and surgical experience is limited.<br />Methods: We reviewed the medical records and optical coherence tomography (OCT) scans in a cohort of eight eyes of seven RP patients with MH in order to report their OCT features and vitreoretinal surgical prognosis.<br />Results: This study includes four lamellar macular holes (LMHs) and four full-thickness macular holes (FTMHs). Pre-operative OCT revealed other macular abnormalities in all eyes, such as epiretinal membrane (ERM), cystoid macular edema (CME), lamellar hole-associated epiretinal proliferation (LHEP) and vitreoretinal traction. MH progression and subjective vision worsening were noted in one LMH eye during a seven-month follow-up. All holes closed after vitrectomy with internal limiting membrane (ILM) peeling. At final follow-up, one eye had improved vision and seven eyes remained stable compared to baseline.<br />Conclusions: The occurrence of MH in RP is accompanied by various imaging characteristics, such as ERM, CME and LHEP, suggesting a multifactorial pathogenesis. Considering poor vision in most RP patients with potentially progressive MH, surgery appears to be effective in maintaining or improving the central vision in a period of time. Thus, vitrectomy should be performed as soon as possible and flap-assisted techniques or episcleral surgeries are needed for some special cases.<br /> (© 2024. The Author(s).)

Details

Language :
English
ISSN :
1471-2415
Volume :
24
Issue :
1
Database :
MEDLINE
Journal :
BMC ophthalmology
Publication Type :
Academic Journal
Accession number :
39187836
Full Text :
https://doi.org/10.1186/s12886-024-03643-y