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Pre- and postoperative OCT features and surgical outcomes of advanced retinitis pigmentosa with macular hole: case series and literature review.
- Source :
-
BMC ophthalmology [BMC Ophthalmol] 2024 Aug 26; Vol. 24 (1), pp. 370. Date of Electronic Publication: 2024 Aug 26. - Publication Year :
- 2024
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Abstract
- Background: Macular hole (MH) is a rare complication of retinitis pigmentosa (RP) and has an adverse impact on residual visual function. At present, the underlying mechanisms are not fully understood and surgical experience is limited.<br />Methods: We reviewed the medical records and optical coherence tomography (OCT) scans in a cohort of eight eyes of seven RP patients with MH in order to report their OCT features and vitreoretinal surgical prognosis.<br />Results: This study includes four lamellar macular holes (LMHs) and four full-thickness macular holes (FTMHs). Pre-operative OCT revealed other macular abnormalities in all eyes, such as epiretinal membrane (ERM), cystoid macular edema (CME), lamellar hole-associated epiretinal proliferation (LHEP) and vitreoretinal traction. MH progression and subjective vision worsening were noted in one LMH eye during a seven-month follow-up. All holes closed after vitrectomy with internal limiting membrane (ILM) peeling. At final follow-up, one eye had improved vision and seven eyes remained stable compared to baseline.<br />Conclusions: The occurrence of MH in RP is accompanied by various imaging characteristics, such as ERM, CME and LHEP, suggesting a multifactorial pathogenesis. Considering poor vision in most RP patients with potentially progressive MH, surgery appears to be effective in maintaining or improving the central vision in a period of time. Thus, vitrectomy should be performed as soon as possible and flap-assisted techniques or episcleral surgeries are needed for some special cases.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Aged
Retrospective Studies
Postoperative Period
Preoperative Period
Tomography, Optical Coherence methods
Retinitis Pigmentosa surgery
Retinitis Pigmentosa complications
Retinitis Pigmentosa physiopathology
Retinal Perforations surgery
Retinal Perforations diagnosis
Retinal Perforations etiology
Visual Acuity physiology
Vitrectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2415
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 39187836
- Full Text :
- https://doi.org/10.1186/s12886-024-03643-y