Back to Search
Start Over
Immune Infiltration Correlates with Transcriptomic Subtypes in Primary ER+ Invasive Lobular Breast Cancer.
- Source :
-
Research square [Res Sq] 2024 Aug 13. Date of Electronic Publication: 2024 Aug 13. - Publication Year :
- 2024
-
Abstract
- Understanding interplay of breast cancer and microenvironment is critical. Here, we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER+/HER2- invasive lobular breast cancers. The proliferative subtype associated with increased immune infiltration especially by immunosuppressive regulatory T-cells and macrophages. We also defined a TAM-Low signature, which associated with lower infiltration of proliferative, pro-inflammatory TAM, and improved outcome in patients with ER+ tumors.
Details
- Language :
- English
- ISSN :
- 2693-5015
- Database :
- MEDLINE
- Journal :
- Research square
- Publication Type :
- Academic Journal
- Accession number :
- 39184073
- Full Text :
- https://doi.org/10.21203/rs.3.rs-4579052/v1