Reply to 'The causal relationship between long-term exposure to ambient fine particulate matter and cognitive performance: Insights from Mendelian randomization'.

Li et al. [1] have commented on our recent paper investigating the association between exposure to fine particulate matter (PM _2.5 ) constituents and the risk of cognitive impairment [2]. They provided a Mendelian randomization (MR) analysis using large-scale genome-wide association study (GWAS) datasets from the European population, confirming a causal relationship between PM _2.5 exposure and cognitive performance. In our reply, we employed three causal inference models, including a generalized propensity score (GPS) adjusted Cox model, an inverse-probability weights (IPW) weighted Cox model, and a trimmed IPW-weighted Cox model, to confirm the relationship of PM _2.5 and cognitive impairment in our study cohort.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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