Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics.

Authors :: Zhang Y
Yu J
Li C
Gong J
Wu Y
Feng L
Chen Z
Sha R
Jiang G
Wang J
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Sep 10; Vol. 60 (73), pp. 9942-9945. Date of Electronic Publication: 2024 Sep 10.
Publication Year :: 2024
Abstract: We designed two series of NIR-II PTAs with D-A or D-A-D structures, in which the introduction of thiophene promotes a bathochromic shift of emission into the NIR-II region, helps to improve the cellular uptake of the PTAs and facilitates NIR-II imaging-guided PDT/PTT cancer phototherapy.

Subjects :: Humans
Photosensitizing Agents chemistry
Photosensitizing Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Photochemotherapy
Neoplasms diagnostic imaging
Neoplasms drug therapy
Neoplasms pathology
Cell Line, Tumor
Cell Survival drug effects
Phototherapy
Optical Imaging
Molecular Structure
Animals
Theranostic Nanomedicine
Thiophenes chemistry
Infrared Rays

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