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Unraveling the immunometabolism puzzle: Deciphering systemic sclerosis pathogenesis.

Unraveling the immunometabolism puzzle: Deciphering systemic sclerosis pathogenesis.

Authors :
Masoumi M
Bodaghi AB
Khorramdelazad H
Ebadi E
Houshmandfar S
Saeedi-Boroujeni A
Karami J
Source :
Heliyon [Heliyon] 2024 Jul 31; Vol. 10 (15), pp. e35445. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).
Publication Year :
2024

Abstract

The article delves into the pathogenesis of systemic sclerosis (SSc) with an emphasis on immunometabolism dysfunctions. SSc is a complex autoimmune connective tissue disorder with skin and organ fibrosis manifestation, vasculopathy, and immune dysregulation. A growing amount of research indicates that immunometabolism plays a significant role in the pathogenesis of autoimmune diseases, including SSc. The review explores the intricate interplay between immune dysfunction and metabolic alterations, focusing on the metabolism of glucose, lipids, amino acids, the TCA (tricarboxylic acid) cycle, and oxidative stress in SSc disease. According to recent research, there are changes in various metabolic pathways that could trigger or perpetuate the SSc disease. Glycolysis and TCA pathways play a pivotal role in SSc pathogenesis through inducing fibrosis. Dysregulated fatty acid β-oxidation (FAO) and consequent lipid metabolism result in dysregulated extracellular matrix (ECM) breakdown and fibrosis induction. The altered metabolism of amino acids can significantly be involved in SSc pathogenesis through various mechanisms. Reactive oxygen species (ROS) production has a crucial role in tissue damage in SSc patients. Indeed, immunometabolism involvement in SSc is highlighted, which offers potential therapeutic avenues. The article underscores the need for comprehensive studies to unravel the multifaceted mechanisms driving SSc pathogenesis and progression.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2024 The Authors.)

Details

Language :
English
ISSN :
2405-8440
Volume :
10
Issue :
15
Database :
MEDLINE
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
39170585
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e35445