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Thrombosis in breast cancer patients on cyclin-dependent kinase inhibitors: Survival impact and predictive factors - A study by the cancer and thrombosis group of the spanish society of medical oncology (SEOM).

Authors :
Sánchez Cánovas M
López Robles J
Adoamnei E
Cacho Lavin D
Diaz Pedroche C
Coma Salvans E
Quintanar Verduguez T
García Verdejo FJ
Cejuela Solís M
García Adrián S
Obispo Portero B
Garrido Fernández A
Salvador Coloma C
Martínez Del Prado MP
Mendiola J
Muñoz Martín AJ
Source :
European journal of internal medicine [Eur J Intern Med] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Thrombosis may be included in the profile of side effects associated with CDK4/6 inhibitors. Its significance might be greater than reported in randomized clinical trials. To investigate this, a retrospective, multicenter study was conducted. The primary objective was to calculate the incidence of thrombosis associated with CDK4/6 inhibitors. Secondary objectives included examining the impact of thrombosis on survival and identifying predictor variables for the development of venous thromboembolism (VTE) or arterial thrombosis (AT). A total of 986 patients were recruited. The incidence of VTE/AT associated with CDK4/6 inhibitor treatment during the follow-up period was 5.48 %. Survival analysis did not indicate that the development of VTE/AT during CDK4/6 inhibitor treatment significantly impacted patient survival (p = 0.133). In our analysis, two variables were found to be statistically significant (p < 0.05) as predictors of VTE/AT in breast cancer patients receiving CDK4/6 inhibitor therapy. These variables were the presence of central nervous system (CNS) metastasis with an odds ratio (OR) of 3.68 (95 % CI 1.18 - 11.49) and the use of abemaciclib with an OR of 2.3 (95 % CI 1.16 - 4.57).<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest related to this article.<br /> (Copyright © 2024. Published by Elsevier B.V.)

Details

Language :
English
ISSN :
1879-0828
Database :
MEDLINE
Journal :
European journal of internal medicine
Publication Type :
Academic Journal
Accession number :
39168715
Full Text :
https://doi.org/10.1016/j.ejim.2024.08.005