Back to Search
Start Over
Discovery and structure-activity relationship study of novel isoxazole-based small molecules targeting Zika virus infections.
- Source :
-
RSC medicinal chemistry [RSC Med Chem] 2024 Jul 22; Vol. 15 (8), pp. 2792-2805. Date of Electronic Publication: 2024 Jul 22 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- The Zika virus (ZIKV), a significant public health threat, is transmitted by Aedes aegypti mosquitoes and is associated with severe neurological disorders, particularly in newborns. Currently, there are no approved vaccines or specific therapeutics for ZIKV. Our study focuses on the identification and optimization of isoxazole-based small molecules, specifically through the structural modification of KR-26827 , to combat ZIKV infections. Among the synthesized derivatives, 7l emerged as the most promising candidate, showing potent antiviral activity against ZIKV strains and an improved safety profile in vitro . This research underlines the potential of 7l for further development as a ZIKV therapeutic agent.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (This journal is © The Royal Society of Chemistry.)
Details
- Language :
- English
- ISSN :
- 2632-8682
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- RSC medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 39157190
- Full Text :
- https://doi.org/10.1039/d4md00240g