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Specific antibody responses to Qβ-displayed Plasmodium falciparum-derived UB05 and MSP3 proteins in mother-neonate couples.
- Source :
-
Scandinavian journal of immunology [Scand J Immunol] 2024 Nov; Vol. 100 (5), pp. e13404. Date of Electronic Publication: 2024 Aug 19. - Publication Year :
- 2024
-
Abstract
- Malaria blood-stage parasite is a critical pathogenic stage responsible for serious adverse outcomes in pregnant women and their neonates. Immunoglobulin G (IgG) antibody responses specific to various asexual blood-stage antigens were well reported in non-pregnant individuals. However, little is still known during placental malaria. To assess the antibody responses specific to Plasmodium falciparum-derived MSP3 and UB05 malaria vaccine candidates in mother-neonate couples, mother's peripheral blood and neonate's cord blood samples were collected at delivery. After malaria diagnostic, plasma levels of IgG and IgG subclass responses specific to UB05, MSP3 and UB05-MSP3 were determined using ELISA. As outcomes, both mothers and neonates had significantly higher IgG responses to UB05 and UB05-MSP3 compared to anti-MSP3 IgG (p < 0.05), irrespective of malaria status. Significant negative correlations were observed between IgG levels specific to the three antigens and parasitaemia (p < 0.01). Anti-UB05 and anti-UB05-MSP3 IgG levels in neonates showed a significant positive correlation with the corresponding mothers' antibodies (r <subscript>s</subscript> = 0.25 with p = 0.04; r <subscript>s</subscript> = 0.31 with p = 0.01, respectively). UB05MSP3-specific IgG3 and IgG1 subclass responses were significantly higher than the IgG4 subclass (p < 0.01). The neonates IgG1 and IgG3 levels positively correlated with the corresponding antibody subclasses of mothers. These findings suggest an association between UB05 and UB05-MSP3-specific antibody responses and malaria control during pregnancy. Maternal-foetal transfer of MSP3 and UB05-specific IgG occurs during pregnancy, suggesting the interest in the future malaria vaccination strategies in pregnant women to generate early protective immunity in baby against malaria.<br /> (© 2024 The Scandinavian Foundation for Immunology.)
- Subjects :
- Humans
Female
Pregnancy
Infant, Newborn
Adult
Malaria Vaccines immunology
Antibody Formation immunology
Male
Young Adult
Plasmodium falciparum immunology
Antibodies, Protozoan immunology
Antibodies, Protozoan blood
Malaria, Falciparum immunology
Malaria, Falciparum parasitology
Immunoglobulin G blood
Immunoglobulin G immunology
Antigens, Protozoan immunology
Protozoan Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3083
- Volume :
- 100
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 39155843
- Full Text :
- https://doi.org/10.1111/sji.13404