Back to Search Start Over

Specific antibody responses to Qβ-displayed Plasmodium falciparum-derived UB05 and MSP3 proteins in mother-neonate couples.

Authors :
Lissom A
Megnekou R
Tchouangueu TF
Ngu L
Djontu JC
Ouambo HF
Sanders C
Tchadji JC
Sake CS
Tchuandom SB
Bawage S
Okoli AS
Park CG
Waffo AB
Godwin NW
Source :
Scandinavian journal of immunology [Scand J Immunol] 2024 Nov; Vol. 100 (5), pp. e13404. Date of Electronic Publication: 2024 Aug 19.
Publication Year :
2024

Abstract

Malaria blood-stage parasite is a critical pathogenic stage responsible for serious adverse outcomes in pregnant women and their neonates. Immunoglobulin G (IgG) antibody responses specific to various asexual blood-stage antigens were well reported in non-pregnant individuals. However, little is still known during placental malaria. To assess the antibody responses specific to Plasmodium falciparum-derived MSP3 and UB05 malaria vaccine candidates in mother-neonate couples, mother's peripheral blood and neonate's cord blood samples were collected at delivery. After malaria diagnostic, plasma levels of IgG and IgG subclass responses specific to UB05, MSP3 and UB05-MSP3 were determined using ELISA. As outcomes, both mothers and neonates had significantly higher IgG responses to UB05 and UB05-MSP3 compared to anti-MSP3 IgG (p < 0.05), irrespective of malaria status. Significant negative correlations were observed between IgG levels specific to the three antigens and parasitaemia (p < 0.01). Anti-UB05 and anti-UB05-MSP3 IgG levels in neonates showed a significant positive correlation with the corresponding mothers' antibodies (r <subscript>s</subscript>  = 0.25 with p = 0.04; r <subscript>s</subscript>  = 0.31 with p = 0.01, respectively). UB05MSP3-specific IgG3 and IgG1 subclass responses were significantly higher than the IgG4 subclass (p < 0.01). The neonates IgG1 and IgG3 levels positively correlated with the corresponding antibody subclasses of mothers. These findings suggest an association between UB05 and UB05-MSP3-specific antibody responses and malaria control during pregnancy. Maternal-foetal transfer of MSP3 and UB05-specific IgG occurs during pregnancy, suggesting the interest in the future malaria vaccination strategies in pregnant women to generate early protective immunity in baby against malaria.<br /> (© 2024 The Scandinavian Foundation for Immunology.)

Details

Language :
English
ISSN :
1365-3083
Volume :
100
Issue :
5
Database :
MEDLINE
Journal :
Scandinavian journal of immunology
Publication Type :
Academic Journal
Accession number :
39155843
Full Text :
https://doi.org/10.1111/sji.13404