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Navigating glioblastoma complexity: the interplay of neurotransmitters and chromatin.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2024 Aug 17; Vol. 51 (1), pp. 912. Date of Electronic Publication: 2024 Aug 17. - Publication Year :
- 2024
-
Abstract
- Glioblastoma is the most aggressive brain cancer with an unfavorable prognosis for patient survival. Glioma stem cells, a subpopulation of cancer cells, drive tumor initiation, self-renewal, and resistance to therapy and, together with the microenvironment, play a crucial role in glioblastoma maintenance and progression. Neurotransmitters such as noradrenaline, dopamine, and serotonin have contrasting effects on glioblastoma development, stimulating or inhibiting its progression depending on the cellular context and through their action on glioma stem cells, perhaps changing the epigenetic landscape. Recent studies have revealed that serotonin and dopamine induce chromatin modifications related to transcriptional plasticity in the mammalian brain and possibly in glioblastoma; however, this topic still needs to be explored because of its potential implications for glioblastoma treatment. Also, it is essential to consider that neurotransmitters' effects depend on the tumor's microenvironment since it can significantly influence the response and behavior of cancer cells. This review examines the possible role of neurotransmitters as regulators of glioblastoma development, focusing on their impact on the chromatin of glioma stem cells.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Epigenesis, Genetic
Dopamine metabolism
Animals
Serotonin metabolism
Gene Expression Regulation, Neoplastic
Glioblastoma metabolism
Glioblastoma genetics
Glioblastoma pathology
Neurotransmitter Agents metabolism
Chromatin metabolism
Brain Neoplasms metabolism
Brain Neoplasms genetics
Brain Neoplasms pathology
Neoplastic Stem Cells metabolism
Neoplastic Stem Cells pathology
Tumor Microenvironment genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 51
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 39153092
- Full Text :
- https://doi.org/10.1007/s11033-024-09853-3