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The role of extracellular matrix hydrogels and adipose-derived stromal cells in soft tissue vascularization - A systematic review.

Authors :
Getova VE
Pinheiro-Machado E
Harmsen MC
Burgess JK
Smink AM
Source :
Biomaterials advances [Biomater Adv] 2024 Nov; Vol. 164, pp. 213986. Date of Electronic Publication: 2024 Aug 09.
Publication Year :
2024

Abstract

Decellularized extracellular matrix (dECM) hydrogels loaded with adipose-derived stromal cells (ASC) or their conditioned medium (ASC CM) present a promising and versatile treatment approach for tissue vascularization and regeneration. These hydrogels are easy to produce, store, personalize, manipulate, and deliver to the target tissue. This literature review aimed to investigate the applications of dECM hydrogels with ASC or ASC CM for in vivo tissue vascularization. Fourteen experimental studies have been reviewed using vessel density as the primary outcome parameter for in vivo vascularization. The studies consistently reported an increased efficacy in augmenting angiogenesis by the ASC or ASC CM-loaded hydrogels compared to untreated controls. However, this systematic review shows the need to standardize procedures and characterization, particularly of the final administered product(s). The findings from these experimental studies highlight the potential of dECM hydrogel with ASC or ASC CM in novel tissue regeneration and regenerative medicine applications.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest. The funders had no role in the study's design, in the collection, analyses, interpretation of data, or the writing of the manuscript.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
2772-9508
Volume :
164
Database :
MEDLINE
Journal :
Biomaterials advances
Publication Type :
Academic Journal
Accession number :
39151272
Full Text :
https://doi.org/10.1016/j.bioadv.2024.213986