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Central and peripheral mechanisms underlying respiratory deficits in a mouse model of accelerated senescence.

Authors :
Lino-Alvarado A
Maia OAC
Oliveira MA
Takakura AC
Tavares-Lima W
Moriya HT
Moreira TS
Source :
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Nov; Vol. 476 (11), pp. 1665-1676. Date of Electronic Publication: 2024 Aug 16.
Publication Year :
2024

Abstract

Aging invariably decreases sensory and motor stimuli and affects several neuronal systems and their connectivity to key brain regions, including those involved in breathing. Nevertheless, further investigation is needed to fully comprehend the link between senescence and respiratory function. Here, we investigate whether a mouse model of accelerated senescence could develop central and peripheral respiratory abnormalities. Adult male Senescence Accelerated Mouse Prone 8 (SAMP8) and the control SAMR1 mice (10 months old) were used. Ventilatory parameters were assessed by whole-body plethysmography, and measurements of respiratory input impedance were performed. SAMP8 mice exhibited a reduction in the density of neurokinin-1 receptor immunoreactivity in the entire ventral respiratory column. Physiological experiments showed that SAMP8 mice exhibited a decreased tachypneic response to hypoxia (FiO2 = 0.08; 10 min) or hypercapnia (FiCO2 = 0.07; 10 min). Additionally, the ventilatory response to hypercapnia increased further due to higher tidal volume. Measurements of respiratory mechanics in SAMP8 mice showed decreased static compliance (Cstat), inspiratory capacity (IC), resistance (Rn), and elastance (H) at different ages (3, 6, and 10 months old). SAMP8 mice also have a decrease in contractile response to methacholine compared to SAMR1. In conclusion, our findings indicate that SAMP8 mice display a loss of the NK1-expressing neurons in the respiratory brainstem centers, along with impairments in both central and peripheral respiratory mechanisms. These observations suggest a potential impact on breathing in a senescence animal model.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Details

Language :
English
ISSN :
1432-2013
Volume :
476
Issue :
11
Database :
MEDLINE
Journal :
Pflugers Archiv : European journal of physiology
Publication Type :
Academic Journal
Accession number :
39150501
Full Text :
https://doi.org/10.1007/s00424-024-03006-y