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Is terbinafine an effective treatment for feline sporotrichosis?
- Source :
-
The Veterinary record [Vet Rec] 2024 Aug 17; Vol. 195 (4), pp. e4435. Date of Electronic Publication: 2024 Aug 15. - Publication Year :
- 2024
-
Abstract
- Background: Terbinafine has been successfully used in the treatment of human sporotrichosis; however, its effectiveness in the treatment of feline sporotrichosis is unknown. Therefore, this study aimed to describe the use of terbinafine in the treatment of feline sporotrichosis.<br />Methods: A cohort study was conducted in cats with sporotrichosis to assess the effectiveness and safety of terbinafine (30‒60 mg/kg/day). Clinical examination and analysis of laboratory parameters were performed monthly until clinical signs resolved or terbinafine treatment was discontinued.<br />Results: Of the 54 cats with sporotrichosis included in the study, 19 were lost during follow-up and five were withdrawn from the study due to switching to treatment with another prescription drug. Of the remaining 30 cats, 10 achieved clinical cure, with a median treatment time of 18.5 weeks. Treatment failed in 18 cases, and two cats died. Twenty-two cats had adverse reactions to terbinafine treatment, and 10 cats showed elevation of serum transaminases.<br />Limitation: Loss during follow-up was high, which makes it difficult to draw accurate conclusions regarding clinical outcomes.<br />Conclusion: The low rate of clinical cure observed suggests that terbinafine does not represent an effective treatment option for cases of feline sporotrichosis.<br /> (© 2024 British Veterinary Association.)
Details
- Language :
- English
- ISSN :
- 2042-7670
- Volume :
- 195
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Veterinary record
- Publication Type :
- Academic Journal
- Accession number :
- 39148234
- Full Text :
- https://doi.org/10.1002/vetr.4435