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Evaluation of the antitumor activity of albendazole using Langmuir-Blodgett monolayers as surface mediated drug delivery system.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2024 Sep 30; Vol. 663, pp. 124586. Date of Electronic Publication: 2024 Aug 13. - Publication Year :
- 2024
-
Abstract
- This study demonstrates the application of Langmuir and Langmuir-Blodgett films as biomimetic drug reservoirs and delivery systems to investigate the effect of an anthelmintic on cancer cell culture. The repurposing of benzimidazole anthelmintics for cancer therapy due to their microtubule-inhibiting properties has gained attention, showing promising anticancer effects and tumor-suppressive properties. Although widely used in medicine, the low aqueous solubility of benzimidazole compounds poses challenges for studying their effects on cancer cells, requiring incorporation into various formulations. Our study demonstrates that incorporating albendazole into stable Palmitic Acid Langmuir monolayers, forming Langmuir-Blodgett films, significantly affects the proliferation of liver carcinoma cells. This report presents the initial findings of the effect of an antitumoral drug on cancer cell culture using a simple and repeatable methodology.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Hep G2 Cells
Cell Line, Tumor
Anthelmintics chemistry
Anthelmintics administration & dosage
Anthelmintics pharmacology
Solubility
Surface Properties
Albendazole chemistry
Albendazole administration & dosage
Albendazole pharmacology
Drug Delivery Systems methods
Antineoplastic Agents chemistry
Antineoplastic Agents administration & dosage
Antineoplastic Agents pharmacology
Cell Proliferation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 663
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 39147249
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2024.124586