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Effect of quercetin and chrysin and its association on viability and cell cycle progression in MDA-MB-231 and MCF-7 human breast cancer cells.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Oct; Vol. 179, pp. 117276. Date of Electronic Publication: 2024 Aug 14. - Publication Year :
- 2024
-
Abstract
- Pharmacological properties of flavonoids have been reported, with an anticancer role amongst them, however, its mechanisms are not fully elucidated. In this study, the activity of quercetin and chrysin towards MCF-7 and MDA-MB-231 breast cancer cells was investigated. Cellular viability was determined after treatment with the compounds in different concentrations for 24 h. Secondly, cells were treated with fixed concentration of chrysin and different concentrations of quercetin with preincubation for 1 h. Both compounds inhibited cellular proliferation in dose-dependent manner. The association showed improvement in their cytotoxicity, more expressively with preincubation of quercetin. Quercetin and chrysin association induced cell cycle arrest in sub-G0/G1 phase in MDA-MB-231 cells, modified the expression of caspases-3 and -8,-8, inducing late apoptosis cell death. Taken together, our results demonstrate that both flavonoids inhibited cells growth in a dose-dependent manner and the association of quercetin improved chrysin's toxic effect over the cell lines.<br />Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interest.<br /> (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Humans
MCF-7 Cells
Female
Cell Line, Tumor
Dose-Response Relationship, Drug
Cell Cycle Checkpoints drug effects
Quercetin pharmacology
Flavonoids pharmacology
Cell Survival drug effects
Breast Neoplasms drug therapy
Breast Neoplasms pathology
Breast Neoplasms metabolism
Cell Cycle drug effects
Cell Proliferation drug effects
Apoptosis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 179
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 39146763
- Full Text :
- https://doi.org/10.1016/j.biopha.2024.117276