Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence.

Authors :: Novo JP
Gee L
Caetano CA
Tomé I
Vilaça A
von Zglinicki T
Moreira IS
Jurk D
Rosa S
Ferreira L
Source :: Aging cell [Aging Cell] 2024 Sep; Vol. 23 (9), pp. e14270. Date of Electronic Publication: 2024 Aug 15.
Publication Year :: 2024
Abstract: BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.<br /> (© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)

Subjects :: Animals
Brain metabolism
Mice
Tight Junctions metabolism
Humans
Blood-Brain Barrier metabolism
Cellular Senescence physiology
Aging physiology
Endothelial Cells metabolism

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