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In situ implantable DNA hydrogel for diagnosis and therapy of postoperative rehemorrhage following intracerebral hemorrhage surgery.
- Source :
-
Science advances [Sci Adv] 2024 Aug 16; Vol. 10 (33), pp. eado3919. Date of Electronic Publication: 2024 Aug 14. - Publication Year :
- 2024
-
Abstract
- Postoperative rehemorrhage following intracerebral hemorrhage surgery is intricately associated with a high mortality rate, yet there is now no effective clinical treatment. In this study, we developed a hemoglobin (Hb)-responsive in situ implantable DNA hydrogel comprising Hb aptamers cross-linked with two complementary chains and encapsulating deferoxamine mesylate (DFO). Functionally, the hydrogel generates signals upon postoperative rehemorrhage by capturing Hb, demonstrating a distinctive "self-diagnosis" capability. In addition, the ongoing capture of Hb mediates the gradual disintegration of the hydrogel, enabling the on-demand release of DFO without compromising physiological iron-dependent functions. This process achieves self-treatment by inhibiting the ferroptosis of neurocytes. In a collagenase and autologous blood injection model-induced mimic postoperative rehemorrhage model, the hydrogel exhibited a 5.58-fold increase in iron absorption efficiency, reducing hematoma size significantly (from 8.674 to 4.768 cubic millimeters). This innovative Hb-responsive DNA hydrogel not only offers a therapeutic intervention for postoperative rehemorrhage but also provides self-diagnosis feedback, holding notable promise for enhancing clinical outcomes.
- Subjects :
- Animals
Deferoxamine pharmacology
Deferoxamine therapeutic use
Deferoxamine chemistry
DNA metabolism
Humans
Male
Rats
Disease Models, Animal
Ferroptosis drug effects
Iron metabolism
Postoperative Hemorrhage etiology
Postoperative Hemorrhage diagnosis
Aptamers, Nucleotide pharmacology
Aptamers, Nucleotide chemistry
Cerebral Hemorrhage diagnosis
Cerebral Hemorrhage drug therapy
Hydrogels chemistry
Hemoglobins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2375-2548
- Volume :
- 10
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Science advances
- Publication Type :
- Academic Journal
- Accession number :
- 39141742
- Full Text :
- https://doi.org/10.1126/sciadv.ado3919