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Insights into the role of glycosyltransferase in the targeted treatment of gastric cancer.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117194. Date of Electronic Publication: 2024 Aug 12. - Publication Year :
- 2024
-
Abstract
- Gastric cancer is a remarkably heterogeneous tumor. Despite some advances in the diagnosis and treatment of gastric cancer in recent years, the precise treatment and curative outcomes remain unsatisfactory. Poor prognosis continues to pose a major challenge in gastric cancer. Therefore, it is imperative to identify effective targets to improve the treatment and prognosis of gastric cancer patients. It should be noted that glycosylation, a novel form of posttranslational modification, is a process capable of regulating protein function and influencing cellular activities. Currently, numerous studies have shown that glycosylation plays vital roles in the occurrence and progression of gastric cancer. As crucial enzymes that regulate glycan synthesis in glycosylation processes, glycosyltransferases are potential targets for treating GC. Hence, investigating the regulation of glycosyltransferases and the expression of associated proteins in gastric cancer cells is highly important. In this review, the related glycosyltransferases and their related signaling pathways in gastric cancer, as well as the existing inhibitors of glycosyltransferases, provide more possibilities for targeted therapies for gastric cancer.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Humans
Animals
Glycosylation
Signal Transduction
Antineoplastic Agents therapeutic use
Antineoplastic Agents pharmacology
Enzyme Inhibitors therapeutic use
Enzyme Inhibitors pharmacology
Stomach Neoplasms drug therapy
Stomach Neoplasms enzymology
Stomach Neoplasms pathology
Glycosyltransferases metabolism
Glycosyltransferases antagonists & inhibitors
Molecular Targeted Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 178
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 39137647
- Full Text :
- https://doi.org/10.1016/j.biopha.2024.117194