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Population genomics uncovers global distribution, antimicrobial resistance, and virulence genes of the opportunistic pathogen Klebsiella aerogenes.
- Source :
-
Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114602. Date of Electronic Publication: 2024 Aug 12. - Publication Year :
- 2024
-
Abstract
- Klebsiella aerogenes is an understudied and clinically important pathogen. We therefore investigate its population structure by genome analysis aligned with metadata. We sequence 130 non-duplicated K. aerogenes clinical isolates and identify two inter-patient transmission events. We then retrieve all publicly available K. aerogenes genomes (n = 1,026, accessed by January 1, 2023) and analyze them with our 130 genomes. We develop a core-genome multi-locus sequence-typing scheme. We find that K. aerogenes is a species complex comprising four phylogroups undergoing evolutionary divergence, likely forming three species. We delineate remarkable clonal diversity and identify three worldwide-distributed carbapenemase-encoding clonal clusters, representing high-risk lineages. We uncover that K. aerogenes has an open genome equipped by a large arsenal of antimicrobial resistance genes. We identify two genetic regions specific for K. aerogenes, encoding a type VI secretion system and flagella/chemotaxis for motility, respectively, both contributing to the virulence. These results provide much-needed insights into the population structure and pan-genomes of K. aerogenes.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Virulence genetics
Humans
Drug Resistance, Bacterial genetics
Phylogeny
Genomics methods
Virulence Factors genetics
Anti-Bacterial Agents pharmacology
Bacterial Proteins genetics
Bacterial Proteins metabolism
Klebsiella Infections microbiology
Klebsiella Infections epidemiology
Enterobacter aerogenes genetics
Enterobacter aerogenes drug effects
Enterobacter aerogenes pathogenicity
Genome, Bacterial
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 39137112
- Full Text :
- https://doi.org/10.1016/j.celrep.2024.114602