Detection of 10 commonly used pharmaceuticals in reef-building stony corals from shallow (5-12 m) and deep (30-40 m) sites in the Red Sea.

Although pharmaceutically-active compounds (PhACs) are increasingly being found to be present in marine environments, their presence in coral reefs, already under threat from various stressors, has remains unexplored. This study focused on PhAC presence in two stony-coral genera, collected from different depths and sites in the Red Sea. The findings reveal the presence of ten different PhACs, with elevated concentrations detected in corals from shallow sites and in areas with heavy human activity. Notably, all samples contained at least one PhAC, with the antibiotic sulfamethoxazole being the most prevalent compound, detected in 93% of the samples, at concentrations ranging from 1.5 to 2080 ng/g dry weight (dw) tissue, with an average concentration of 106 ng/g dw. These findings underscore the urgent need for conservation initiatives aimed at protecting coral-reef ecosystems from the escalating threat of anthropogenic contamination, including such potential risks as the development of antibiotic resistance in marine organisms and the disruption of critical spawning synchrony among coral populations.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Noa Shenkar reports financial support was provided as a grant by the Israel Science Foundation - National Natural Science Foundation of China (ISF-NSFC) joint scientific research program. There are no other competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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