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Anti-Interferon-γ Therapy for Cytokine Storm Syndromes.
- Source :
-
Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1448, pp. 573-582. - Publication Year :
- 2024
-
Abstract
- A vast body of evidence provides support to a central role of exaggerated production of interferon-γ (IFN-γ) in causing hypercytokinemia and signs and symptoms of hemophagocytic lymphohistiocytosis (HLH). In this chapter, we will describe briefly the roles of IFN-γ in innate and adaptive immunity and in host defense, summarize results from animal models of primary HLH and secondary HLH with particular emphasis on targeted therapeutic approaches, review data on biomarkers associated with activation of the IFN-γ pathway, and discuss initial efficacy and safety results of IFN-γ neutralization in humans.<br /> (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
- Subjects :
- Humans
Animals
Adaptive Immunity drug effects
Cytokine Release Syndrome immunology
Cytokine Release Syndrome drug therapy
Cytokine Release Syndrome etiology
Interferon-gamma immunology
Lymphohistiocytosis, Hemophagocytic immunology
Lymphohistiocytosis, Hemophagocytic drug therapy
Immunity, Innate drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2598
- Volume :
- 1448
- Database :
- MEDLINE
- Journal :
- Advances in experimental medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 39117840
- Full Text :
- https://doi.org/10.1007/978-3-031-59815-9_38