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Single-cell sequencing has revealed a more complex array of thymic epithelial cells.
- Source :
-
Immunology letters [Immunol Lett] 2024 Oct; Vol. 269, pp. 106904. Date of Electronic Publication: 2024 Aug 06. - Publication Year :
- 2024
-
Abstract
- Thymic epithelial cells participate in the maturation and selection of T lymphocytes. This review explores recent insights from single-cell sequencing regarding classifying thymic epithelial cells in both normal and neoplastic thymus. Cortical thymic epithelial cells facilitate thymocyte differentiation and contribute to positive selection. Medullary epithelial cells are distinguished by their expression of AIRE. Cells progress from a pre-AIRE state, containing precursors with cortical and medullary characteristics, termed junctional cells. Mature medullary epithelial cells exhibit promiscuous gene expression and after that downregulate AIRE mRNA. Post-AIRE cells can adopt a Hassall corpuscle-like phenotype or exhibit distinctive differentiation characteristics including tuft cells, ionocytes, neuroendocrine cells, and myoid cells.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Animals
AIRE Protein
Thymocytes metabolism
Thymocytes cytology
Thymocytes immunology
Thymus Gland cytology
Thymus Gland metabolism
Thymus Gland immunology
Epithelial Cells metabolism
Single-Cell Analysis methods
Cell Differentiation
Transcription Factors metabolism
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0542
- Volume :
- 269
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 39117004
- Full Text :
- https://doi.org/10.1016/j.imlet.2024.106904