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Hippocampus-specific knockdown of Shati/Nat8l impairs cognitive function and electrophysiological response in mice.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 22; Vol. 736, pp. 150435. Date of Electronic Publication: 2024 Jul 22. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Shati/Nat8l was identified as an upregulated molecule in the nucleus accumbens (NAc) of mice following repeated methamphetamine administration. Region-specific roles of this molecule are associated with psychiatric disorders. In the present study, we examined the importance of Shati/Nat8l in the hippocampus because of its high expression in this region. Mice with a hippocampus-specific knockdown of Shati/Nat8l (hippocampal Shati-cKD) were prepared by the microinjection of adeno-associated virus (AAV) vectors carrying Cre into the hippocampus of Shati/Nat8l <superscript>flox/flox</superscript> mice, and their phenotypes were investigated. Drastic reduction in the expression and function of Shati/Nat8l in the hippocampus was observed in Shati-cKD mice. These mice exhibited cognitive dysfunction in behavioral experiments and impaired the electrophysiological response to the stimuli, which elicits long-term potentiation. Shati/Nat8l in the hippocampus is suggested to possibly play an important role in synaptic plasticity to maintain cognitive function. This molecule could be a therapeutic target for hippocampus-related disorders such as dementia.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2024. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 736
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 39116682
- Full Text :
- https://doi.org/10.1016/j.bbrc.2024.150435