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Does Severity of Donor Acute Kidney Injury Influence Outcomes Following Kidney Transplantation?
- Source :
-
Clinical transplantation [Clin Transplant] 2024 Aug; Vol. 38 (8), pp. e15425. - Publication Year :
- 2024
-
Abstract
- Introduction: The study purpose was to review retrospectively our single-center experience transplanting kidneys from deceased donors (DD) with acute kidney injury (AKI) according to terminal serum creatinine (tSCr) level.<br />Methods: AKI kidneys were defined by a doubling of the DD's admission SCr and a tSCr ≥ 2.0 mg/dL.<br />Results: From 1/07 to 11/21, we transplanted 236 AKI DD kidneys, including 100 with a tSCr ≥ 3.0 mg/dL (high SCr AKI group, mean tSCr 4.2 mg/dL), and the remaining 136 from DDs with a tSCr of 2.0-2.99 mg/dL (lower SCr AKI group, mean tSCr 2.4 mg/dL). These two AKI groups were compared to 996 concurrent control patients receiving DD kidneys with a tSCr < 1.0 mg/dL. Mean follow-up was 69 months. Delayed graft function (DGF) rates were 51% versus 46% versus 29% (p < 0.0001), and 5-year patient and death-censored kidney graft survival rates were 96.8% versus 83.5% versus 82.2% (p = 0.002) and 86.7% versus 77.8% versus 78.8% (p = 0.18) in the high tSCr AKI versus lower tSCr AKI versus control groups, respectively.<br />Conclusions: Despite a higher incidence of DGF, patients receiving kidneys from DDs with tSCr levels ≥3.0 mg/dL have acceptable medium-term outcomes compared to either AKI DDs with a lower tSCr or DDs with a tSCr < 1.0 mg/dL.<br /> (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Follow-Up Studies
Prognosis
Survival Rate
Graft Rejection etiology
Glomerular Filtration Rate
Risk Factors
Delayed Graft Function etiology
Adult
Kidney Function Tests
Postoperative Complications etiology
Creatinine blood
Severity of Illness Index
Kidney Failure, Chronic surgery
Acute Kidney Injury etiology
Kidney Transplantation adverse effects
Tissue Donors supply & distribution
Graft Survival
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 39113644
- Full Text :
- https://doi.org/10.1111/ctr.15425