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Health-related quality of life is an independent predictor of mortality and hospitalisations in transthyretin amyloid cardiomyopathy: a prospective cohort study.
- Source :
-
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2024 Oct; Vol. 33 (10), pp. 2743-2753. Date of Electronic Publication: 2024 Aug 06. - Publication Year :
- 2024
-
Abstract
- Purpose: Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with severely impaired health-related quality of life (HRQL). HRQL is an independent predictor of outcome in heart failure (HF), but data on patients with ATTR-CM is scarce. This study therefore aims to evaluate the association of HRQL with outcome in ATTR-CM.<br />Methods: Patients from our prospective ATTR-CM registry were assessed using the Kansas City cardiomyopathy questionnaire (KCCQ), the Minnesota living with HF questionnaire (MLHFQ), and the EuroQol five dimensions questionnaire (EQ-5D). Cox regression analysis was utilised to assess the impact of HRQL on all-cause mortality.<br />Results: 167 patients [80 years; interquartile range (IQR): 76-84; 80.8% male] were followed for a median of 27.6 (IQR: 9.7-41.8) months. The primary endpoint of all-cause mortality was met by 43 (25.7%) patients after a median period of 16.2 (IQR: 9.1-28.1) months. In a univariate Cox regression for mortality, a 10-point change in the KCCQ implied a hazard ratio (HR) of 0.815 [95%-confidence interval (CI): 0.725-0.916; p = 0.001], in the EQ-5D VAS of 0.764 (95%-CI: 0.656-0.889; p < 0.001), and 1.163 (95%-CI: 1.114-1.433; p < 0.001) in the MLHFQ. After adjustment for established biomarkers of HF, all-cause mortality was predicted independently by the EQ-5D VAS (HR: 0.8; 95%-CI: 0.649-0.986; p = 0.037; per 10 points) and the MLHFQ (HR: 1.228; 95%-CI: 1.035-1.458; p = 0.019; per 10 points).<br />Conclusion: HRQL is a predictor of outcome in ATTR-CM. The EQ-5D VAS and the MLHFQ predict survival independent of biomarkers of HF.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Prospective Studies
Aged
Aged, 80 and over
Surveys and Questionnaires
Proportional Hazards Models
Heart Failure mortality
Heart Failure psychology
Quality of Life psychology
Amyloid Neuropathies, Familial mortality
Amyloid Neuropathies, Familial psychology
Cardiomyopathies mortality
Cardiomyopathies psychology
Hospitalization statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2649
- Volume :
- 33
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 39105960
- Full Text :
- https://doi.org/10.1007/s11136-024-03723-y