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Feasibility and efficacy of cell-free and concentrate ascites reinfusion therapy (CART) for advanced pancreatic cancer patients with massive malignant ascites.
- Source :
-
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2024 Sep; Vol. 24 (6), pp. 925-929. Date of Electronic Publication: 2024 Jul 31. - Publication Year :
- 2024
-
Abstract
- Background: The management of malignant ascites is critical for treating patients with advanced pancreatic cancer. The purpose of this study was to assess the safety of cell-free and concentrated ascites reinfusion therapy (CART) and its impact on the prognosis of patients with advanced pancreatic cancer who have massive malignant ascites.<br />Methods: This study analyzed 47 procedures in 29 patients who underwent CART for ascites caused by pancreatic cancer between 2015 and 2022. Among them, 7 patients who received chemotherapy following CART were classified as the chemotherapy group, while 22 patients without chemotherapy after CART were classified as the palliative care group.<br />Results: Among the 47 procedures, adverse events (AEs) were observed in 9 procedures (19 %). Grade 2 adverse events were observed only in one procedure, manifested as fever. There were no grade 3 or 4 AEs, nor were there any treatment-related deaths. The median survival time was 4.0 months in the chemotherapy group and 0.7 months in the palliative care group (p = 0.004). The albumin level in the chemotherapy group was significantly higher than that in the palliative care group.<br />Conclusion: CART is feasible and might be the optimal option to enable prolonged use of chemotherapy to improve the prognosis for late-stage pancreatic cancer patients.<br />Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest.<br /> (Copyright © 2024 IAP and EPC. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Male
Female
Aged
Middle Aged
Feasibility Studies
Treatment Outcome
Aged, 80 and over
Adult
Retrospective Studies
Prognosis
Antineoplastic Agents therapeutic use
Antineoplastic Agents adverse effects
Pancreatic Neoplasms complications
Pancreatic Neoplasms therapy
Ascites therapy
Ascites etiology
Palliative Care methods
Subjects
Details
- Language :
- English
- ISSN :
- 1424-3911
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
- Publication Type :
- Academic Journal
- Accession number :
- 39103254
- Full Text :
- https://doi.org/10.1016/j.pan.2024.07.013