Back to Search
Start Over
Evaluation of the anti-aging potential of acetyl tripeptide-30 citrulline in cosmetics.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2024 Sep 30; Vol. 663, pp. 124557. Date of Electronic Publication: 2024 Aug 03. - Publication Year :
- 2024
-
Abstract
- Acetyl tripeptide-30 citrulline, a commercialized bio-active peptide, is widely used in anti-wrinkle formulations. Volunteer-based tests have demonstrated that topical application of products containing acetyl tripeptide-30 citrulline significantly reduces the visibility of stretch marks. However, there is still a lack of research dedicated to systematically and holistically evaluating its cosmetic properties and elucidating its mechanisms of action. In this study, we assessed the cosmetic potential of acetyl tripeptide-30 citrulline using human immortalized keratinocytes (HaCaT) and mouse embryonic fibroblasts (3T3). Our findings reveal that acetyl tripeptide-30 citrulline exhibits anti-inflammatory and antioxidant activities in skin cells, particularly effective against the inflammatory markers cyclooxygenase-2 (COX2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), and the extent of inhibition of reactive oxygen species (ROS) production ranged from 95 % to 340 %. Moreover, acetyl tripeptide-30 citrulline specifically up-regulates Collagen IV and down-regulates matrix metalloproteinase-9 (MMP9), enhances the expression of skin barrier proteins transglutaminase 1 (TGM1) and filaggrin (FLG), thereby demonstrating its reparative capabilities. Additionally, acetyl tripeptide-30 citrulline increases the expression of the water channel protein aquaporin 3 (AQP3), thus improving skin hydration function. These results substantiate the previously proclaimed cosmetic attributes of acetyl tripeptide-30 citrulline and support its efficacy as an anti-aging agent in dermatological applications.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Animals
Mice
Citrulline pharmacology
Transglutaminases metabolism
Keratinocytes drug effects
Keratinocytes metabolism
Skin Aging drug effects
Reactive Oxygen Species metabolism
Oligopeptides pharmacology
Oligopeptides administration & dosage
Fibroblasts drug effects
Fibroblasts metabolism
HaCaT Cells
Matrix Metalloproteinase 9 metabolism
Cell Line
Skin metabolism
Skin drug effects
Filaggrin Proteins
Cosmetics pharmacology
Cosmetics administration & dosage
Antioxidants pharmacology
Antioxidants administration & dosage
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 663
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 39103061
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2024.124557