Mediastinitis caused by an NDM-1 Escherichia coli in a child with Dacron Sano shunt after pulmonary atresia with ventricular septal defect surgery treated with combination of aztreonam-avibactam.

Authors :: Cousin VL
Miatello J
Sierra R
Sologashvili T
Wacker J
Andrey DO
L'Huillier AG
Source :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2024 Oct; Vol. 64 (4), pp. 107295. Date of Electronic Publication: 2024 Aug 02.
Publication Year :: 2024
Abstract: Carbapenem-resistant Enterobacterales are being reported increasingly and cause nosocomial infections, which may include postoperative mediastinitis. This paper reports a case of postoperative mediastinitis caused by an Escherichia coli NDM-1 carbapenemase producer in a 13-month-old boy with DiGeorge syndrome. The infection was managed with surgical debridement and antibiotherapy with aztreonam, ceftazidime-avibactam and IV fosfomycin for 6 weeks. The evolution was favourable, without relapse over 10 weeks of follow-up.<br /> (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Subjects :: Humans
Male
Infant
Pulmonary Atresia surgery
Heart Septal Defects, Ventricular surgery
Ceftazidime therapeutic use
Treatment Outcome
Aztreonam therapeutic use
beta-Lactamases genetics
Anti-Bacterial Agents therapeutic use
Azabicyclo Compounds therapeutic use
Escherichia coli genetics
Escherichia coli drug effects
Escherichia coli isolation & purification
Escherichia coli Infections drug therapy
Escherichia coli Infections microbiology
Mediastinitis microbiology
Mediastinitis drug therapy
Drug Combinations

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