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A persistent mineralization process in alveolar bone throughout the postnatal growth stage in rats.
- Source :
-
Archives of oral biology [Arch Oral Biol] 2024 Nov; Vol. 167, pp. 106062. Date of Electronic Publication: 2024 Jul 30. - Publication Year :
- 2024
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Abstract
- Objective: Alveolar bone quality is essential for the maxillofacial integrity and function, and depends on alveolar bone mineralization. This study aims to investigate the in vivo changes in alveolar bone mineralization, from the perspective of mineral deposition and crystal transition in postnatal rats.<br />Design: Nine postnatal time points of Wistar rats, ranging from day 1 to 56, were set to obtain the maxillary alveolar bone samples. Each time point consisted of ninety rats, with 45 females and 45 males. Macromorphology of alveolar bone was reconducted by Micro-Computed Tomography and the mineral content was quantified via Thermogravimetric analysis, Scanning Electron Microscope, High-Resolution Transmission Electron Microscopy and vibrational spectroscopy. Furthermore, the crystallinity and composition were characterized by vibrational spectroscopy, X-ray Diffraction, X-ray Photoelectron Spectroscopy and Selected Area Electron Diffraction.<br />Results: The progressive increase of mineral deposition was accompanied by substantial growth in alveolar bone mass and volume in postnatal rats. Whereas the mineral percentage initially decreased and then increased, reaching a nadir on postnatal day 14 (P14) when tooth eruption was first observed. Besides, localized mineralization was initiated by the formation of amorphous precursors and then converted into mineral crystals, while there was no statistically significant change in the average crystallinity of the bone during growth.<br />Conclusion: Mineralization of alveolar bone is ongoing throughout the early growth in postnatal rats. Mineral deposition increases with age, whereas the crystallinity remains stable within a certain range. Besides, the mineral percentage reaches its lowest point on P14, which may be attributed to tooth eruption.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Rats
Female
Male
X-Ray Diffraction
Microscopy, Electron, Transmission
Thermogravimetry
Bone Density
Photoelectron Spectroscopy
Maxilla growth & development
Rats, Wistar
X-Ray Microtomography
Calcification, Physiologic physiology
Alveolar Process growth & development
Alveolar Process diagnostic imaging
Alveolar Process metabolism
Microscopy, Electron, Scanning
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1506
- Volume :
- 167
- Database :
- MEDLINE
- Journal :
- Archives of oral biology
- Publication Type :
- Academic Journal
- Accession number :
- 39094423
- Full Text :
- https://doi.org/10.1016/j.archoralbio.2024.106062