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Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review).
- Source :
-
International journal of oncology [Int J Oncol] 2024 Sep; Vol. 65 (3). Date of Electronic Publication: 2024 Aug 02. - Publication Year :
- 2024
-
Abstract
- The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance, metabolic reprogramming, immunomodulatory effects and autophagy. Yes‑associated protein 1 (YAP1), a potent transcriptional coactivator and a major downstream target tightly controlled by the Hippo pathway, is influenced by various molecules and pathways. The expression of YAP1 in different cell types within the liver tumor microenvironment exerts varying effects on tumor outcomes, warranting careful consideration. Therefore, research on YAP1‑targeted therapies merits attention. This review discusses the composition and regulation mechanism of the Hippo/YAP1 signaling pathway and its relationship with HCC, offering insights for future research and cancer prevention strategies.
- Subjects :
- Humans
Tumor Microenvironment drug effects
Molecular Targeted Therapy methods
Antineoplastic Agents therapeutic use
Antineoplastic Agents pharmacology
Gene Expression Regulation, Neoplastic drug effects
Cell Proliferation drug effects
Animals
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular metabolism
Carcinoma, Hepatocellular pathology
Liver Neoplasms drug therapy
Liver Neoplasms metabolism
Liver Neoplasms pathology
Transcription Factors metabolism
Signal Transduction drug effects
Hippo Signaling Pathway
YAP-Signaling Proteins metabolism
Adaptor Proteins, Signal Transducing metabolism
Protein Serine-Threonine Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-2423
- Volume :
- 65
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of oncology
- Publication Type :
- Academic Journal
- Accession number :
- 39092548
- Full Text :
- https://doi.org/10.3892/ijo.2024.5676