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Antibacterial and mechanism of action studies of boxazomycin A.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2024 Oct; Vol. 77 (10), pp. 679-684. Date of Electronic Publication: 2024 Aug 01. - Publication Year :
- 2024
-
Abstract
- Boxazomycins A-C are potent broad-spectrum antibiotics isolated from Actinomycetes strain G495-1 in 1987. We now report that boxazomycin A inhibits bacterial growth by selectively inhibiting protein synthesis, its effect is bacteriostatic, and it is equally active against drug resistant bacterial strains. No cross-resistance to protein synthesis inhibitors was observed suggesting that its inhibition is distinct from clinical protein synthesis inhibitors. We also report in vivo efficacy in a Staphylococcus aureus murine infection model supported by corresponding pharmacokinetic studies.<br /> (© 2024. Merck & Co., Inc., Rahway, NJ, USA and its affiliates, under exclusive licence to the Japan Antibiotics Research Association.)
- Subjects :
- Animals
Mice
Protein Synthesis Inhibitors pharmacology
Drug Resistance, Bacterial drug effects
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Microbial Sensitivity Tests
Staphylococcal Infections drug therapy
Staphylococcal Infections microbiology
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 77
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 39090325
- Full Text :
- https://doi.org/10.1038/s41429-024-00757-9