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Acupuncture Modulation of Chronic Neuropathic Pain and Its Association With Brain Functional Properties.
- Source :
-
The journal of pain [J Pain] 2024 Nov; Vol. 25 (11), pp. 104645. Date of Electronic Publication: 2024 Jul 30. - Publication Year :
- 2024
-
Abstract
- Chronic neuropathic pain has been one of the prominent causes of disability, and acupuncture has shown promise in treatment. The present study aimed to characterize acupuncture modulation of chronic neuropathic pain and explore the related functional brain changes. Sixty chronic sciatica patients were divided into acupuncture- or sham acupuncture groups and received 10 sessions of treatment during 4 weeks. The visual analog scale for leg pain, oswestry disability index (ODI), and resting-state functional magnetic resonance images were assessed at baseline and after treatment. Then, fractional amplitudes of low-frequency fluctuations (fALFF) and support vector regression analyses were performed. Compared with sham acupuncture, acupuncture significantly improved symptoms, including visual analog scale for leg pain and ODI. In addition, acupuncture exhibited increased fALFF of the right superior parietal lobule (SPL) and right postcentral gyrus. Furthermore, the actual 4-week ODI values were positively correlated with the support vector regression-predicted values based on the right SPL fALFF and baseline clinical measurements. These results indicate that the spontaneous neural activity of the right SPL and right postcentral gyrus may be involved in the modulation of acupuncture in chronic neuropathic pain. In addition, the spontaneous neural activity of the right SPL might be used as the predictor of response to acupuncture therapy. PERSPECTIVE: This clinical neuroimaging study elucidated the neural basis of acupuncture in chronic sciatica. Neurological indicators and clinical measurements could be used as potential predictors of acupuncture response. This study combines neuroimaging and artificial intelligence techniques to highlight the potential of acupuncture for the treatment of chronic neuropathic pain. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Registry, ChiCTR2100044585, http://www.chictr.org.cn.<br /> (Copyright © 2024 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Brain physiopathology
Brain diagnostic imaging
Sciatica therapy
Sciatica physiopathology
Pain Measurement
Treatment Outcome
Magnetic Resonance Imaging
Acupuncture Therapy
Neuralgia therapy
Neuralgia physiopathology
Neuralgia diagnostic imaging
Chronic Pain therapy
Chronic Pain physiopathology
Chronic Pain diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1528-8447
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The journal of pain
- Publication Type :
- Academic Journal
- Accession number :
- 39089662
- Full Text :
- https://doi.org/10.1016/j.jpain.2024.104645