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ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice.
- Source :
-
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2024 Dec; Vol. 1869 (8), pp. 159546. Date of Electronic Publication: 2024 Jul 31. - Publication Year :
- 2024
-
Abstract
- ABCA1 plays an essential role in the formation of high-density lipoprotein (HDL), and its mutations cause Tangier disease (TD), a familial HDL deficiency. In addition to the disappearance of HDL, TD patients exhibit cholesterol deposition in peripheral tissues through a mechanism poorly understood, which may contribute to the development of premature atherosclerosis. We and others previously showed that ABCA1 deficiency causes hyperactivation of the SREBP2 pathway in vitro. Here, we show using Abca1 knockout mice that ABCA1 deficiency leads to tissue-specific dysregulation of SREBP2 activity in a nutritional status-dependent manner, which may underlie the pathophysiology of TD.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Mice
Tangier Disease genetics
Tangier Disease metabolism
Tangier Disease pathology
Signal Transduction genetics
Lipoproteins, HDL metabolism
Lipoproteins, HDL genetics
Organ Specificity genetics
Cholesterol metabolism
Humans
Mice, Inbred C57BL
ATP Binding Cassette Transporter 1 genetics
ATP Binding Cassette Transporter 1 metabolism
ATP Binding Cassette Transporter 1 deficiency
Sterol Regulatory Element Binding Protein 2 metabolism
Sterol Regulatory Element Binding Protein 2 genetics
Mice, Knockout
Subjects
Details
- Language :
- English
- ISSN :
- 1879-2618
- Volume :
- 1869
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta. Molecular and cell biology of lipids
- Publication Type :
- Academic Journal
- Accession number :
- 39089642
- Full Text :
- https://doi.org/10.1016/j.bbalip.2024.159546