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Prospective close monitoring of the effect of vascular-targeted photodynamic therapy and high intensity focused ultrasound of localized prostate cancer by multiparametric magnetic resonance imaging.
- Source :
-
World journal of urology [World J Urol] 2024 Aug 01; Vol. 42 (1), pp. 462. Date of Electronic Publication: 2024 Aug 01. - Publication Year :
- 2024
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Abstract
- Purpose: The aim of this study is to describe the anatomical and functional changes observed in multiparametric magnetic resonance imaging (mpMRI) during follow-up after focal therapy (FT) for localized prostate cancer (PCa).<br />Materials and Methods: In this prospective study, we analyzed pre- and postoperatively acquired mpMRI of 10 patients after FT (7 days; 3, 6, 9, 12 months). 7/10 (70%) patients underwent vascular-targeted photodynamic therapy (VTP). 3/10 (30%) patients underwent high-intensity focused ultrasound (HIFU). MpMR image analysis was performed using a semi-automatic software for segmentation of the prostate gland (PG) and tumor zones. Signal intensities (SI) of T2-weighted (T2w), T1-weighted (T1w),diffusion-weighted (DWI) and dynamic contrast-enhanced (DCE) images as well as volumes of the prostate gland (PGV) and tumor volumes (TV) were evaluated at each time point.<br />Results: The results showed a significant increase of PGV 7 days after FT (p = 0.042) and a significant reduction of PGV between 7 days and 6, 9 and 12 months after FT (p < 0.001). The TV increased significantly 7 days after FT (p < 0.001) and decreased significantly between 7 days and 12 months after FT (p < 0.001). There was a significant increase in SI of the ADC in the ablation zone after 6, 9 and 12 months after FT (p < 0.001). 1/9 patients (11%) had recurrent tumor on rebiopsy characterized as a a small focal lesion on mpMRI with strong diffusion restriction (low SI on ADC map and high SI on b-value DWI).<br />Conclusion: MpMRI is able to represent morphologic changes of the ablated zone after FT and might be helpful to detect recurrent tumor.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Humans
Male
Prospective Studies
Aged
Middle Aged
Photosensitizing Agents therapeutic use
Combined Modality Therapy
Ultrasound, High-Intensity Focused, Transrectal methods
Prostate diagnostic imaging
Prostate pathology
High-Intensity Focused Ultrasound Ablation methods
Bacteriochlorophylls therapeutic use
Prostatic Neoplasms diagnostic imaging
Prostatic Neoplasms pathology
Prostatic Neoplasms therapy
Prostatic Neoplasms drug therapy
Photochemotherapy methods
Multiparametric Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1433-8726
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 39088086
- Full Text :
- https://doi.org/10.1007/s00345-024-05143-6