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N 6 -methyladenosine (m 6 A) RNA modification in chronic myeloid leukemia: unveiling a novel therapeutic target.
- Source :
-
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Jul 31; Vol. 81 (1), pp. 326. Date of Electronic Publication: 2024 Jul 31. - Publication Year :
- 2024
-
Abstract
- N <superscript>6</superscript> -methyladenosine (m <superscript>6</superscript> A), the most prevalent internal mRNA modification, plays a critical role in physiological processes by regulating gene expression through modulation of mRNA metabolism at multiple stages. In recent years, m <superscript>6</superscript> A has garnered significant attention for a deeper understanding of the initiation, progression, and drug resistance of various cancers, including hematological malignancies. Dysregulation of m <superscript>6</superscript> A has been implicated in both cancer promotion and suppression. m <superscript>6</superscript> A methylation is a complex regulatory process involving methyltransferases (writers), demethylases (erasers), and proteins that recognize specific m <superscript>6</superscript> A modifications (readers). This intricate interplay presents challenges for precisely modulating m <superscript>6</superscript> A levels, either globally or at specific sites. This review specifically focuses on the role of m <superscript>6</superscript> A in chronic myeloid leukemia (CML), a blood cancer characterized by the BCR-ABL1 fusion. We emphasize its impact on leukemia cell survival and drug resistance mechanisms. Notably, inhibitors targeting m <superscript>6</superscript> A regulators show promise in preclinical models, suggesting a potential therapeutic avenue for CML. Integrating our understanding of m <superscript>6</superscript> A biology with current treatment strategies may lead to more effective therapies, especially for patients with advanced-stage or resistant CML.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Drug Resistance, Neoplasm genetics
Animals
Methyltransferases metabolism
Methyltransferases antagonists & inhibitors
Methyltransferases genetics
RNA, Messenger genetics
RNA, Messenger metabolism
Methylation
Adenosine analogs & derivatives
Adenosine metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-9071
- Volume :
- 81
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cellular and molecular life sciences : CMLS
- Publication Type :
- Academic Journal
- Accession number :
- 39085650
- Full Text :
- https://doi.org/10.1007/s00018-024-05379-w