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Heterogeneity of claudin 18.2 expression in metastatic gastric cancer.
- Source :
-
Scientific reports [Sci Rep] 2024 Jul 31; Vol. 14 (1), pp. 17648. Date of Electronic Publication: 2024 Jul 31. - Publication Year :
- 2024
-
Abstract
- Claudin 18.2 has emerged as a viable therapeutic target in gastric cancer (GC), but little is known about the heterogeneity of its expression in GC. This study investigated the heterogeneity of claudin 18.2 expression in 166 patients with metastatic GC whose surgical or paired primary-metastatic specimens were available. The prevalence of claudin 18.2 positivity (moderate-to-strong expression in ≥ 75% by the 43-14A clone) was 47.0%. Claudin 18.2-positive tumors exhibited more frequent peritoneal metastasis and a lower incidence of hepatic and distant lymph node involvement. Survival outcomes were comparable between patients with claudin 18.2-positive and -negative tumors. Intratumoral heterogeneity was noted in 38.5% of surgical specimens. Paired primary-metastatic site analysis revealed that 25.2% of patients had discordant results for claudin 18.2 positivity. Across different metastatic organ categories, peritoneal lesions showed the highest positivity rate (44.3%) and positive concordance rate (31.4%), whereas liver lesions had the lowest positivity rate (17.9%) and concordance rate (12.8%). In conclusion, claudin 18.2 expression exhibits intratumoral and intrapatient spatial heterogeneity in metastatic GC. Claudin 18.2 positivity is associated with more frequent peritoneal metastasis, and peritoneal lesions are more likely to have positively concordant claudin 18.2 results with the primary site than other metastatic sites.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Aged
Biomarkers, Tumor metabolism
Neoplasm Metastasis
Adult
Peritoneal Neoplasms secondary
Peritoneal Neoplasms metabolism
Aged, 80 and over
Lymphatic Metastasis
Prognosis
Liver Neoplasms secondary
Liver Neoplasms metabolism
Stomach Neoplasms pathology
Stomach Neoplasms metabolism
Stomach Neoplasms genetics
Claudins metabolism
Claudins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39085339
- Full Text :
- https://doi.org/10.1038/s41598-024-68411-w