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Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice.
- Source :
-
Nature communications [Nat Commun] 2024 Jul 31; Vol. 15 (1), pp. 6457. Date of Electronic Publication: 2024 Jul 31. - Publication Year :
- 2024
-
Abstract
- Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat mood disorders. The mechanisms of action include an increase in extracellular level of serotonin, neurogenesis, and growth of vessels in the brain. We investigated whether fluoxetine could have broader peripheral regenerative properties. Following prolonged administration of fluoxetine in male mice, we showed that fluoxetine increases the number of muscle stem cells and muscle angiogenesis, associated with positive changes in skeletal muscle function. Fluoxetine also improved skeletal muscle regeneration after single and multiples injuries with an increased muscle stem cells pool and vessel density associated with reduced fibrotic lesions and inflammation. Mice devoid of peripheral serotonin treated with fluoxetine did not exhibit beneficial effects during muscle regeneration. Specifically, pharmacological, and genetic inactivation of the 5-HT1B subtype serotonin receptor also abolished the enhanced regenerative process induced by fluoxetine. We highlight here a regenerative property of serotonin on skeletal muscle.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Male
Mice
Mice, Inbred C57BL
Stem Cells drug effects
Stem Cells metabolism
Stem Cells cytology
Neovascularization, Physiologic drug effects
Selective Serotonin Reuptake Inhibitors pharmacology
Regeneration drug effects
Muscle, Skeletal drug effects
Muscle, Skeletal metabolism
Fluoxetine pharmacology
Serotonin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 39085209
- Full Text :
- https://doi.org/10.1038/s41467-024-50220-4