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18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2024; Vol. 47 (7), pp. 1392-1395. - Publication Year :
- 2024
-
Abstract
- 18-β-Glycyrrhetinic acid, a major component of licorice, stimulated the proliferation of both dermal papilla cells and outer root sheath cells isolated from human hair follicles. Thus, suggesting that this compound promotes hair growth. Furthermore, this compound inhibited the activity of testosterone 5α-reductase, an enzyme responsible for converting androgen to dihydroandrogen, with an IC <subscript>50</subscript> of 137.1 µM. 18-β-Glycyrrhetinic acid also suppressed the expression of transforming growth factor-β1 (TGF-β1), which shifts the hair cycle from the anagen phase to the telogen phase. It suggested that this compound may prolong the anagen phase. Based on these findings, this compound could be a potentially effective treatment for androgenetic alopecia.
- Subjects :
- Humans
Cells, Cultured
Hair growth & development
Hair drug effects
Transforming Growth Factor beta1 metabolism
Alopecia drug therapy
3-Oxo-5-alpha-Steroid 4-Dehydrogenase metabolism
3-Oxo-5-alpha-Steroid 4-Dehydrogenase genetics
Glycyrrhetinic Acid pharmacology
Glycyrrhetinic Acid analogs & derivatives
Cell Proliferation drug effects
Hair Follicle drug effects
Hair Follicle cytology
5-alpha Reductase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 47
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 39085137
- Full Text :
- https://doi.org/10.1248/bpb.b24-00302